Relationship between human genetics and susceptibility to COVID-19

Preetinder Kaur; Pawanjot Kaur

doi:10.52679/tabcj.2020.0007

Authors

Preetinder Kaur (Independent Researcher), 1508, 146 Ave, NW, Edmonton, Alberta, T5Y2X9, Canada https://orcid.org/0000-0001-8049-6082
Pawanjot Kaur (Independent Researcher), Don Bosco Senior Secondary School, Jharmari, Punjab, India

DOI:

https://doi.org/10.52679/tabcj.2020.0007

Keywords:

ACE2, COVID-19, HLA, polymorphism, SARS-CoV-2, viral infection

Abstract

Recent studies have shown that the progression of SARS-CoV-2 is associated with human genetic factors. Many patients have shown diverse clinical symptoms based on their age, sex, ABO blood type, underlying medical conditions, HLA system, and viral variants found in their samples. SARS-CoV-2 is considered more transmissible with higher morbidity rates as compared to the previous SARS outbreak. Several case studies have supported the direct relation of cardiovascular and pulmonary fatalities related to ACE2 polymorphisms during COVID-19 infection. SARS-COV-2 mutants and human genome polymorphisms are vital predictive markers in finding a cure for this pandemic. This review focuses on some of the critical genetic factors of the host that affect the array of immunological responses as a result of COVID-19 infection among individuals.