Parkinson's disease caused by diabetes mellitus: pathophysiology and potential treatments

Authors

  • Priyanka Thagunna Department of Biotechnology, School of Applied and Life Sciences, Uttaranchal University, Dehradun (248007), Uttarakhand, India.
  • Priya Chaudhary Department of Biotechnology, School of Applied and Life Sciences, Uttaranchal University, Dehradun (248007), Uttarakhand, India. https://orcid.org/0000-0001-7901-0006

DOI:

https://doi.org/10.52679/tabcj.2024.0006

Keywords:

brain, insulin resistance, Parkinson's disease, signaling pathway, type 2 diabetes mellitus

Abstract

There have been growing indications that persons with Type 2 diabetes mellitus (T2DM) have a higher risk of getting Parkinson's. Insulin is the hormone responsible for energy metabolism and glucose regulation. However, several reports have demonstrated that insulin can pass across the brain-blood junction and affect multiple processes within the brain. Furthermore, there has been increasing proof that an event similar to peripheral insulin insensitivity takes place in the brains of Parkinson's disease individuals, regardless of diabetes. This brings up the notion that faulty glucose signaling pathways are to blame for the emergence of pathological aspects of Parkinson's disease (PD), implying that the glucose signaling pathway could be an alternative target for disease management. After identifying the linkages between Parkinson's disease and T2DM, it is perhaps not unexpected that medications used to treat T2DM and phytotherapy are among the most effective therapy options being prioritized as innovative treatments for PD. Thus, this study explored the shared pathogenic mechanisms and metabolic pathways that link DM and Parkinson's disease with different PD therapies.

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Published

30-06-2024

How to Cite

Thagunna, P., & Chaudhary, P. (2024). Parkinson’s disease caused by diabetes mellitus: pathophysiology and potential treatments. The Applied Biology & Chemistry Journal, 5(2), 34-43. https://doi.org/10.52679/tabcj.2024.0006

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